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Lunesta dosage information in more detail. No overall differences in safety or effectiveness were observed between subjects 65 years of age and older and younger subjects. There were an insufficient number of patients older than 75 years of age and older in the clinical trials to permit safety or efficacy conclusions in this age-group. No dosage adjustment is needed in generic Zofran Pills patients. Hepatic Impairment No dosage adjustment is needed in patients with mild or moderate hepatic impairment.
In patients with severe hepatic impairment, clearance is reduced and the apparent volume of distribution is increased, resulting in a significant increase in the half-life of ondansetron. Renal Impairment No dosage adjustment is recommended for patients with any degree of renal impairment mild, moderate, or severe. Patients should be managed with appropriate supportive therapy. In addition to the adverse reactions listed above, the following adverse reactions have been described in the setting of ondansetron overdose: Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed.
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Patients required supportive care, including intubation in some cases, with complete recovery without sequelae within 1 to 2 days. While its mechanism of action has not been generic Zofran Pills characterized, ondansetron is not a dopamine -receptor antagonist. Serotonin receptors of the 5- HT 3 generic Zofran Pills are generic Zofran Pills both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine.
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The released serotonin may stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex. Pharmacodynamics In Lagligt Köpa Zenegra På Nätet half-life are seen in patients older than 75 years compared to generic Zofran Pills subjects. Sex Gender differences were shown in the disposition of ondansetron generic Zofran Pills as a single dose, Generic Zofran Pills.
The extent and rate of absorption are greater in women than men. Slower clearance in women, a smaller apparent volume of distribution adjusted for weight, and higher absolute bioavailability resulted in higher plasma ondansetron concentrations.
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